Format

Send to

Choose Destination
Neuron. 1999 Jan;22(1):157-66.

Response of hippocampal synapses to natural stimulation patterns.

Author information

1
Howard Hughes Medical Institute, Molecular Neurobiology Lab, The Salk Institute, La Jolla, California 92037, USA. dobrunz@axp1.salk.edu

Abstract

We have studied the synaptic responses in hippocampal slices to stimulus patterns derived from in vivo recordings of place cell firing in a behaving rodent. We find that synaptic strength is strongly modulated during the presentation of these natural stimulus trains, varying 2-fold or more because of short-term plasticity. This modulation of synaptic strength is precise and deterministic, because the pattern of synaptic response amplitudes is nearly identical from one presentation of the train to the next. The mechanism of synaptic modulation is primarily a change in release probability rather than a change in the size of the elementary postsynaptic response. In addition, natural stimulus trains are effective in inducing long-term potentiation (LTP). We conclude that short-term synaptic plasticity--facilitation, augmentation, and depression--plays a prominent role in normal synaptic function.

PMID:
10027298
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center