Format

Send to

Choose Destination
Dement Geriatr Cogn Disord. 1999 Mar-Apr;10(2):89-96.

White matter lesions in Alzheimer patients are influenced by apolipoprotein E genotype.

Author information

1
Radiology, Division of Geriatric Medicine, Huddinge University Hospital, Huddinge, Sweden. lena.bronge@radiol.hs.sll.se

Abstract

To analyse the influence of apolipoprotein E (APOE) genotype on the extent of white matter lesions (WMLs) in Alzheimer's disease (AD), we examined 60 AD patients with magnetic resonance imaging. The WMLs were rated visually in different brain regions. The patients with the APOE genotype sigma4/4 had more extensive WMLs in the deep white matter than patients with genotypes sigma3/3 and sigma3/4. There was a correlation with age for WMLs in the deep white matter in patients with the APOE sigma3/3 genotype. In patients carrying at least one sigma4 allele, the WMLs showed no age correlation. The results could imply that in APOE allele sigma4 carriers, the WMLs represent a pathological process related to the aetiology of the disease.

PMID:
10026381
DOI:
10.1159/000017107
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center