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Immunity. 1999 Jan;10(1):117-25.

BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in B cells.

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1
Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, Moriguchi, Japan.

Abstract

Signaling through the B cell receptor (BCR) is essential for B cell function and development. Despite the key role of Syk in BCR signaling, little is known about the mechanism by which Syk transmits downstream effectors. BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)gamma 2 and JNK. The BCR-induced PLC gamma 2 activation, but not the JNK activation, was restored by introduction of PLC gamma 2 membrane-associated form into BLNK-deficient B cells. As JNK activation requires both Rac1 and PLC gamma 2, our results suggest that BLNK regulates the Rac1-JNK pathway, in addition to modulating PLC gamma 2 localization.

PMID:
10023776
DOI:
10.1016/s1074-7613(00)80012-6
[Indexed for MEDLINE]
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