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Eur Neurol. 1999;41 Suppl 1:14-9.

Biological actions of nerve growth factor in the peripheral nervous system.

Author information

1
Genentech, Inc., South San Francisco, Calif. 94080, USA. rask.cynthia@gene.com

Abstract

Since the discovery of nerve growth factor (NGF), its role in the physiology/pathophysiology of nerve function has been under intense investigation. More recently, the potential of recombinant human NGF (rhNGF) as a putative treatment for peripheral neuropathies, in particular diabetic polyneuropathy and HIV-associated sensory neuropathy, is being explored. In animal models of diabetes, depletion of endogenous NGF levels has been demonstrated in foot skin and skeletal muscle; these levels reduce further with increasing disease duration. Preclinical studies in animal models of diabetes have shown that administration of NGF can reverse or alleviate impairment in nerve function.

PMID:
10023124
DOI:
10.1159/000052075
[Indexed for MEDLINE]

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