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Bioorg Med Chem Lett. 1999 Jan 18;9(2):209-12.

Parallel synthesis of 1,2,4-oxadiazoles using CDI activation.

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1
Argonaut Technologies, San Carlos, CA 94070, USA.

Abstract

1,2,4-Oxadiazoles have been prepared in parallel using 1,1'-carbonyldiimidazole (CDI) as a reagent for both formation and cyclodehydration of O-acyl benzamidoximes. The use of CDI facilitates parallel purification of the oxadiazole products by simple liquid-liquid extraction and filtration.

PMID:
10021930
DOI:
10.1016/s0960-894x(98)00712-4
[Indexed for MEDLINE]

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