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Bioorg Med Chem Lett. 1999 Jan 18;9(2):151-6.

Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.

Author information

1
Merck Frosst Centre for Therapeutic Research, Merck Frosst Canada Inc., Pointe Claire-Dorval, Qu├ębec, Canada.

Abstract

Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl-2-thiazolylthio)-5-methanesulfonamido-3H-isobe nzofuran-1-one 14 was found to be the optimal compound in the series with superior in vitro and in vivo activities.

PMID:
10021918
DOI:
10.1016/s0960-894x(98)00705-7
[Indexed for MEDLINE]

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