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Chem Biol. 1999 Feb;6(2):R39-48.

How do peptide synthetases generate structural diversity?

Author information

1
Philipps-Universit├Ąt Marburg, Fachbereich Chemie/Biochemie, Germany.

Abstract

Many low-molecular-weight peptides of microbial origin are synthesized nonribosomally on large multifunctional proteins, termed peptide synthetases. These enzymes contain repeated building blocks in which several defined domains catalyze specific reactions of peptide synthesis. The order of these domains within the enzyme determines the sequence and structure of the peptide product.

PMID:
10021423
DOI:
10.1016/S1074-5521(99)80002-7
[Indexed for MEDLINE]
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