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Curr Opin Chem Biol. 1999 Feb;3(1):95-9.

Membrane organization in immunoglobulin E receptor signaling.

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Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853-1301, USA.


The structure and dynamics of the plasma membrane are proposed to be critical for the initial steps of signal transduction by the high-affinity immunoglobulin E receptor. Recent experimental advances indicate that interactions between the high-affinity immunoglobulin E receptor and the tyrosine kinase Lyn with cholesterol- and sphingolipid-rich regions within the plasma membrane are important for receptor function. This accumulating evidence points to spatio-temporal control of immunoglobulin E receptor signaling by the organization of the plasma membrane; an attractive hypothesis is that ligand-dependent receptor aggregation causes the segregation of Lyn-containing ordered regions of the plasma membrane from disordered regions.

[Indexed for MEDLINE]

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