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Curr Opin Chem Biol. 1999 Feb;3(1):77-83.

How does radiation kill cells?

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Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA.


Recent advances in the understanding of intracellular signaling after genotoxic injury have led to a better understanding of the pathways that influence radiation-induced cell death. Particular progress has been made in defining molecular controls of apoptosis and radiation-induced cell cycle arrest, as well as the possible role of telomerase activity in stabilizing DNA breaks.

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