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Curr Biol. 1999 Feb 11;9(3):R93-6.

Intracellular signalling: PDK1--a kinase at the hub of things.

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1
Diabetes Unit and Medical Services, Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA.

Abstract

Phosphoinositide-dependent kinase 1 (PDK1) is at the hub of many signalling pathways, activating PKB and PKC isoenzymes, as well as p70 S6 kinase and perhaps PKA. PDK1 action is determined by colocalization with substrate and by target site availability, features that may enable it to operate in both resting and stimulated cells.

PMID:
10021376
[Indexed for MEDLINE]
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