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Nat Cell Biol. 2005 May;7(5):474-82. Epub 2005 Apr 17.

The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium.

Author information

1
Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Erratum in

  • Nat Cell Biol. 2005 Jun;7(6):637.

Abstract

In the developing brain, the organization of the neuroepithelium is maintained by a critical balance between proliferation and cell-cell adhesion of neural progenitor cells. The molecular mechanisms that underlie this are still largely unknown. Here, through analysis of a conditional knockout mouse for the Kap3 gene, we show that post-Golgi transport of N-cadherin by the KIF3 molecular motor complex is crucial for maintaining this balance. N-cadherin and beta-catenin associate with the KIF3 complex by co-immunoprecipitation, and colocalize with KIF3 in cells. Furthermore, in KAP3-deficient cells, the subcellular localization of N-cadherin was disrupted. Taken together, these results suggest a potential tumour-suppressing activity for this molecular motor.

PMID:
15834408
DOI:
10.1038/ncb1249
[Indexed for MEDLINE]

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