Format

Send to

Choose Destination
Curr Opin Cell Biol. 1997 Oct;9(5):691-700.

Integrin signaling: specificity and control of cell survival and cell cycle progression.

Author information

1
Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, Cornell University, New York, NY 10021, USA. f-giancotti@ski.mskcc.org

Abstract

Integrin-mediated adhesion to the extracellular matrix plays an important role in regulating cell survival and proliferation. There is now increasing evidence that integrins activate shared as well as subgroup-specific signaling pathways. The signals from these adhesion receptors are integrated with those originating from growth factor and cytokine receptors in order to organize the cytoskeleton, stimulate mitogen-activated protein kinase cascades, and regulate immediate early gene expression. The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors.

PMID:
9330873
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center