Format

Send to

Choose Destination
Nature. 1997 Feb 13;385(6617):602-9.

Crystal structure of the Src family tyrosine kinase Hck.

Author information

1
Laboratories of Molecular Biophysics, The Rockefeller University, New York 10021, USA.

Abstract

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

Comment in

PMID:
9024658
DOI:
10.1038/385602a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center