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Trends Biochem Sci. 1994 Mar;19(3):129-34.

The three-dimensional structure of a molecular motor.

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Department of Biochemistry, Institute for Enzyme Research, Madison, WI 53705.


Myosin is one of only three proteins known to convert chemical energy into mechanical work. Although the chemical, kinetic and physiological characteristics of this protein have been studied extensively, it has been difficult to define its molecular basis of movement. With the recent X-ray structural determination of the myosin head, however, it is now possible to put forward a hypothesis on how myosin might function as a molecular motor.

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