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Biochem Biophys Res Commun. 1988 Nov 30;157(1):196-202.

Classification of the insulin-like growth factor binding proteins into three distinct categories according to their binding specificities.

Author information

1
Department of Biochemistry, University of Adelaide, Australia.

Abstract

Competitive binding experiments with insulin-like growth factor (IGF)-1, IGF-2 and des-(1-3)-IGF-1 have confirmed the interpretation based on limited amino-terminal sequence analysis that at least three types of IGF binding protein occur. In addition to the acid stable subunit of the large serum binding protein which exhibits des-(1-3)-IGF-1 binding only slightly less than IGF-1, the small IGF binding proteins can be separated into two classes based on differences in des-(1-3)-IGF-1 and IGF-2 binding potencies.

PMID:
2973786
DOI:
10.1016/s0006-291x(88)80032-9
[Indexed for MEDLINE]

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