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Year Number of Results
1993 1
1995 2
1997 6
1998 8
1999 17
2000 18
2001 24
2002 31
2003 25
2004 37
2005 30
2006 5
2007 9
2008 17
2009 8
2010 16
2011 25
2012 26
2013 29
2014 45
2015 50
2016 66
2017 54
2018 81
2019 70
2020 78
2021 59
2022 34
2023 23
2024 9

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804 results

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Page 1
Epidemiology and biology of early onset colorectal cancer.
Venugopal A, Carethers JM. Venugopal A, et al. EXCLI J. 2022 Jan 7;21:162-182. doi: 10.17179/excli2021-4456. eCollection 2022. EXCLI J. 2022. PMID: 35221839 Free PMC article. Review.
Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in men or women in the United States. Average-risk screening that begins at age 50 years has reduced incidence and mortality of CRC in those over 50 years of age, whereas CRC incidence in …
Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in men or women in the United States. Average-r …
TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/beta-catenin degradation and is targeted for GSK3B/GSK3beta-mediated phosphorylation and degradation.
Wu H, Lu XX, Wang JR, Yang TY, Li XM, He XS, Li Y, Ye WL, Wu Y, Gan WJ, Guo PD, Li JM. Wu H, et al. Autophagy. 2019 Sep;15(9):1506-1522. doi: 10.1080/15548627.2019.1586250. Epub 2019 Mar 4. Autophagy. 2019. PMID: 30806153 Free PMC article.
Aberrant CTNNB1 signaling is one of the fundamental processes in cancers, especially colorectal cancer (CRC). ...Pharmacological inhibition of GSK3B activity stabilized the TRAF6 protein, promoted CTNNB1 degradation, and effectively suppressed EMT and …
Aberrant CTNNB1 signaling is one of the fundamental processes in cancers, especially colorectal cancer (CRC). ...Pharma …
Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review).
Katoh M. Katoh M. Int J Mol Med. 2018 Aug;42(2):713-725. doi: 10.3892/ijmm.2018.3689. Epub 2018 May 17. Int J Mol Med. 2018. PMID: 29786110 Free PMC article. Review.
beta-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E-cadherin/CDH1, N-cadherin/CDH2, VE-cadherin/CDH5 and alpha-catenins), transmembrane-type mucins (MUC1/CD227 and MUC16/CA125), signaling regulators (APC, AXIN1, AXIN2 and NHER …
beta-catenin/CTNNB1 is an intracellular scaffold protein that interacts with adhesion molecules (E-cadherin/CDH1, N-cadherin/CDH2, VE …
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.
Yaeger R, Chatila WK, Lipsyc MD, Hechtman JF, Cercek A, Sanchez-Vega F, Jayakumaran G, Middha S, Zehir A, Donoghue MTA, You D, Viale A, Kemeny N, Segal NH, Stadler ZK, Varghese AM, Kundra R, Gao J, Syed A, Hyman DM, Vakiani E, Rosen N, Taylor BS, Ladanyi M, Berger MF, Solit DB, Shia J, Saltz L, Schultz N. Yaeger R, et al. Cancer Cell. 2018 Jan 8;33(1):125-136.e3. doi: 10.1016/j.ccell.2017.12.004. Cancer Cell. 2018. PMID: 29316426 Free PMC article.
We identified splice alterations in intronic regions of APC and large in-frame deletions in CTNNB1, increasing oncogenic WNT pathway alterations to 96% of CRCs. ...
We identified splice alterations in intronic regions of APC and large in-frame deletions in CTNNB1, increasing oncogenic WNT pathway …
Transcriptional Regulation of Wnt/beta-Catenin Pathway in Colorectal Cancer.
Bian J, Dannappel M, Wan C, Firestein R. Bian J, et al. Cells. 2020 Sep 19;9(9):2125. doi: 10.3390/cells9092125. Cells. 2020. PMID: 32961708 Free PMC article. Review.
Aberrant activation of the pathway is implicated in growth-associated diseases and cancers, especially as a key driver in the initiation and progression of colorectal cancer (CRC). Loss or inactivation of Adenomatous polyposis coli (APC) results in constitutive acti …
Aberrant activation of the pathway is implicated in growth-associated diseases and cancers, especially as a key driver in the initiation and …
Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting beta-catenin degradation.
Liu C, Wang L, Liu X, Tan Y, Tao L, Xiao Y, Deng P, Wang H, Deng Q, Lin Y, Jie H, Zhang H, Zhang J, Peng Y, Zhang H, Zhou Z, Sun Q, Cen X, Zhao Y. Liu C, et al. Theranostics. 2021 Jan 1;11(6):2966-2986. doi: 10.7150/thno.48699. eCollection 2021. Theranostics. 2021. PMID: 33456583 Free PMC article.
However, the nonmetabolic function of SHMT2 in tumorigenesis, especially in human colorectal cancer (CRC) progression, remains largely unclear. Methods: SHMT2 expression in human CRC cells was identified by western blot and immunofluorescence assay. ...
However, the nonmetabolic function of SHMT2 in tumorigenesis, especially in human colorectal cancer (CRC) progression, remains …
The lncRNA NEAT1 activates Wnt/beta-catenin signaling and promotes colorectal cancer progression via interacting with DDX5.
Zhang M, Weng W, Zhang Q, Wu Y, Ni S, Tan C, Xu M, Sun H, Liu C, Wei P, Du X. Zhang M, et al. J Hematol Oncol. 2018 Sep 5;11(1):113. doi: 10.1186/s13045-018-0656-7. J Hematol Oncol. 2018. PMID: 30185232 Free PMC article.
BACKGROUND: The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has been reported to be overexpressed in colorectal cancer (CRC). However, its underlying mechanisms in the progression of CRC have not been well studied. ...CONCLUSIONS: Our findings …
BACKGROUND: The long noncoding RNA nuclear-enriched abundant transcript 1 (NEAT1) has been reported to be overexpressed in colorectal …
SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial-mesenchymal transition by beta-catenin and Beclin1/autophagy signaling in colorectal cancer.
Zhu Y, Huang S, Chen S, Chen J, Wang Z, Wang Y, Zheng H. Zhu Y, et al. Cell Death Dis. 2021 May 5;12(5):449. doi: 10.1038/s41419-021-03733-5. Cell Death Dis. 2021. PMID: 33953166 Free PMC article.
Our previous study has demonstrated the oncogenic role of SOX2 in colorectal cancer (CRC). In this study, we sought to elucidate the underlying mechanisms. ...
Our previous study has demonstrated the oncogenic role of SOX2 in colorectal cancer (CRC). In this study, we sought to elucida …
CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1.
Zhang L, Dong X, Yan B, Yu W, Shan L. Zhang L, et al. Cell Death Dis. 2020 Jul 17;11(7):542. doi: 10.1038/s41419-020-2707-6. Cell Death Dis. 2020. PMID: 32681092 Free PMC article.
Colorectal cancer (CRC) is a common malignancy with high occurrence and mortality worldwide. ...Importantly, circAGFG1 activated Wnt/beta-catenin pathway through regulating CTNNB1. Afterwards, YY1 was found to transcriptionally activate CTNNB1. ...
Colorectal cancer (CRC) is a common malignancy with high occurrence and mortality worldwide. ...Importantly, circAGFG1 activat …
LncRNA PART1 regulates colorectal cancer via targeting miR-150-5p/miR-520h/CTNNB1 and activating Wnt/beta-catenin pathway.
Zhou T, Wu L, Ma N, Tang F, Zong Z, Chen S. Zhou T, et al. Int J Biochem Cell Biol. 2020 Jan;118:105637. doi: 10.1016/j.biocel.2019.105637. Epub 2019 Oct 24. Int J Biochem Cell Biol. 2020. PMID: 31669140
PART1, as an identified lncRNA, was an oncogene in several cancers. However, the underling mechanism of PART1 regulating colorectal cancer remains unknown. qRT-PCR was used to measure relevant RNAs expression. ...Mechanistically, PART1 sponged miR-150-5p/miR-520 h t …
PART1, as an identified lncRNA, was an oncogene in several cancers. However, the underling mechanism of PART1 regulating colorectal …
804 results