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J Laryngol Otol. 2018 Jul;132(7):568-574. doi: 10.1017/S0022215118000968. Epub 2018 Jun 18.

How phenotype guides management of the neuroendocrine carcinomas of the larynx.

Author information

1
Department of Otolaryngology,Hospital Universitario Central de Asturias,Oviedo,Spain.
2
Department of Pathology,University of Arkansas for Medical Sciences,Little Rock,USA.
3
Department of Otolaryngology Head and Neck Surgery,NHS Lothian, Edinburgh,UK.
4
University of Udine School of Medicine,Udine,Italy.
5
Department of Pathology,University of Texas MD Anderson Cancer Center,Houston,USA.
6
Department of Anatomic Pathology,Hospital Clinic, University of Barcelona,Spain.
7
Coordinator of the International Head and Neck Scientific Group,Padua,Italy.

Abstract

OBJECTIVE:

This review aimed to critically analyse data pertaining to the clinical presentation and treatment of neuroendocrine carcinomas of the larynx.

METHOD:

A PubMed search was performed using the term 'neuroendocrine carcinoma'. English-language articles on neuroendocrine carcinoma of the larynx were reviewed in detail.Results and conclusionWhile many historical classifications have been proposed, in contemporary practice these tumours are sub-classified into four subtypes: carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma and large cell neuroendocrine carcinoma. These tumours exhibit a wide range of biological behaviour, ranging from the extremely aggressive nature of small and large cell neuroendocrine carcinomas, which usually have a fatal prognosis, to the less aggressive course of carcinoid tumours. In small and large cell neuroendocrine carcinomas, a combination of irradiation and chemotherapy is indicated, while carcinoid and atypical carcinoid tumour management entails conservation surgery.

KEYWORDS:

Carcinoid Tumors; Laryngeal Cancer; Larynx; Neuroendocrine Carcinoma; Neuroendocrine Tumors

PMID:
29909787
DOI:
10.1017/S0022215118000968
[Indexed for MEDLINE]

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