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Sci Rep. 2018 Jan 18;8(1):1141. doi: 10.1038/s41598-018-19258-5.

First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness.

Author information

1
Istituto Nazionale di Fisica Nucleare- Laboratori Nazionali dei Sud, via S. Sofia, 62, Catania, Italy. pablo.cirrone@lns.infn.it.
2
Physics Department, University of Naples Federico II, Naples, Italy.
3
INFN Naples Section, Complesso Universitario di Monte S. Angelo, Via Cintia, Naples, Italy.
4
Institute of Physics ASCR, v.v.i. (FZU), ELI-Beamlines Project, Na Slovance 2, Prague, 18221, Czech Republic.
5
Istituto Nazionale di Fisica Nucleare- Laboratori Nazionali dei Sud, via S. Sofia, 62, Catania, Italy.
6
Physics Department, University of Catania, via S. Sofia, 64, Catania, Italy.
7
Fondazione Bruno Kessler, Micro-Nano Facility, Via Sommarive 18, 38123, Povo-Trento, Italy.
8
Institute of Molecular Bioimaging and Physiology - National Research Council - (IBFM-CNR), Cefalù, (PA), Italy.
9
National Physical Laboratory, Acoustic and Ionizing Radiation Division, Teddington, TW11 0LW, Middlesex, United Kingdom.

Abstract

Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) 12C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper 12C-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + 11B → 3α reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses 10B-enriched BSH for neutron irradiation-triggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy's ballistic precision with the higher RBE promised by BNCT and 12C-ion therapy is thus demonstrated.

PMID:
29348437
PMCID:
PMC5773549
DOI:
10.1038/s41598-018-19258-5
[Indexed for MEDLINE]
Free PMC Article

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