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Mutat Res. 2018 Jul;810:45-51. doi: 10.1016/j.mrfmmm.2017.10.003. Epub 2017 Nov 7.

Biological effects of carbon ion beams with various LETs on budding yeast Saccharomyces cerevisiae.

Author information

1
Research Institute of Nuclear Engineering, University of Fukui, Tsuruga, Fukui, 914-0055, Japan.
2
National Institutes for Quantum and Radiological Science and Technology, National Institute of Radiological Sciences, Chiba, 263-8555, Japan.
3
Radioisotope Research Center, Osaka University, Toyonaka, Osaka 560-0043, Japan. Electronic address: y-matsuo@u-fukui.ac.jp.

Abstract

It has been established that irradiation with higher linear energy transfer (LET) increases lethality and mutagenicity more than that with lower LET. However, the characteristics specific to carbon ion beam have not yet been elucidated. Yeast cells were irradiated with carbon ions with an LET of 13 or 50keV/μm, and cell survival and mutation frequency were analyzed. The results, combined with our previous findings for ions with an LET of 107keV/μm, demonstrated that, in conjunction with an increase in LET, cell survival decreased, while mutation frequency increased. This indicates that a carbon ion beam with a higher LET is more mutagenic than one with a lower LET.

PMID:
29146154
DOI:
10.1016/j.mrfmmm.2017.10.003
[Indexed for MEDLINE]

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