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Respirology. 2017 Jul;22(5):1007-1014. doi: 10.1111/resp.13013. Epub 2017 Feb 22.

A 7-year follow-up study of obstructive sleep apnoea in healthy elderly: The PROOF cohort study.

Author information

1
Department of Clinical Physiology, Centre VISAS, CHU Nord, University Hospital of Saint Etienne, EA 4607 SNA EPIS, University of Lyon (UDL), Jean Monnet University, Saint-Etienne, France.

Abstract

BACKGROUND AND OBJECTIVE:

Clinical and epidemiological cohort studies have shown that obstructive sleep apnoea (OSA) is a common but largely undiagnosed disorder in senior subjects, where progressive deterioration of the pathology would be expected as a consequence of the ageing processes. Our study examines the longitudinal progression of OSA over a 7-year period in a community-based sample of healthy subjects.

METHODS:

The sample consisted of 284 volunteers, aged >65 years (52% women, 48% men) accepting clinical and instrumental follow-up at 7 years. OSA was defined as an apnoea-hypopnoea index (AHI) of ≥15.

RESULTS:

Between evaluations in the total sample, AHI slightly decreased from 17.8 ± 14 to 16.7 ± 11 with a decrease affecting more the hypopnoea index (P < 0.001) and associated with significant changes (P < 0.001) in all indices of hypoxaemia. While in the non-OSA group there was a slight but significant increase of AHI, a significant AHI decrease was noted in mild-moderate patients (P < 0.01) and a significant rise of nocturnal hypoxaemia in severe OSA patients (P < 0.001). The AHI decrease was not associated with clinical, weight, metabolic and blood pressure changes between the two evaluations; the baseline AHI value being the only factor correlated to the degree of AHI decline.

CONCLUSIONS:

In elderlies, the severity and prevalence of OSA decrease progressively with ageing without effect of factors commonly influencing OSA severity. This trend may support the hypothesis that in healthy elderly, OSA is a phenomenon related to ageing.

KEYWORDS:

elderly; longitudinal evolution; obstructive sleep apnoea; physiopathology

PMID:
28225159
DOI:
10.1111/resp.13013
[Indexed for MEDLINE]

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