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Antimicrob Agents Chemother. 2015 Jul;59(7):4352-5. doi: 10.1128/AAC.00614-15. Epub 2015 May 4.

Determination of MIC distribution and epidemiological cutoff values for bedaquiline and delamanid in Mycobacterium tuberculosis using the MGIT 960 system equipped with TB eXiST.

Author information

1
Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland Nationales Referenzzentrum für Mykobakterien, Universität Zürich, Zürich, Switzerland pkeller@imm.uzh.ch.
2
Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland Nationales Referenzzentrum für Mykobakterien, Universität Zürich, Zürich, Switzerland.
3
Institut für Medizinische Mikrobiologie, Universität Zürich, Zürich, Switzerland.

Abstract

Bedaquiline (Sirturo) and delamanid (Deltyba) have recently been approved by the regulatory authorities for treatment of multidrug-resistant tuberculosis (MDR-TB). Antimicrobial susceptibility testing is not established for either substance. On the basis of the use of the MGIT 960 system equipped with EpiCenter/TB eXiST, we determined a mean bedaquiline MIC for wild-type strains of 0.65 mg/liter (median, 0.4 mg/liter) and an epidemiological cutoff (ECOFF) of 1.6 mg/liter; for delamanid, a mean wild-type drug MIC of 0.013 mg/liter (median, 0.01 mg/liter) and an ECOFF of 0.04 mg/liter were determined.

PMID:
25941226
PMCID:
PMC4468675
DOI:
10.1128/AAC.00614-15
[Indexed for MEDLINE]
Free PMC Article

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