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Sci Rep. 2015 Apr 23;5:9555. doi: 10.1038/srep09555.

Antibacterial activity of silver-killed bacteria: the "zombies" effect.

Author information

1
Institute of Chemistry and the Center for Nanoscience and Nanotechnology, the Hebrew University of Jerusalem, Jerusalem 91904, Israel.
2
1] Institute of Chemistry and the Center for Nanoscience and Nanotechnology, the Hebrew University of Jerusalem, Jerusalem 91904, Israel [2] Department of Environmental Health, Hadassah Academic College, Jerusalem 91010, Israel.

Abstract

We report a previously unrecognized mechanism for the prolonged action of biocidal agents, which we denote as the zombies effect: biocidally-killed bacteria are capable of killing living bacteria. The concept is demonstrated by first killing Pseudomonas aeruginosa PAO1 with silver nitrate and then challenging, with the dead bacteria, a viable culture of the same bacterium: Efficient antibacterial activity of the killed bacteria is observed. A mechanism is suggested in terms of the action of the dead bacteria as a reservoir of silver, which, due to Le-Chatelier's principle, is re-targeted to the living bacteria. Langmuirian behavior, as well as deviations from it, support the proposed mechanism.

PMID:
25906433
PMCID:
PMC5386105
DOI:
10.1038/srep09555
[Indexed for MEDLINE]
Free PMC Article

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