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Neural Regen Res. 2013 Jul 25;8(21):2003-14. doi: 10.3969/j.issn.1673-5374.2013.21.009.

Oxidative stress, mitochondrial damage and neurodegenerative diseases.

Author information

1
Department of Pharmacy, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
2
Life Science Research Center, Hebei North University, Zhangjiakou 075000, Hebei Province, China.
3
Department of Human Anatomy and Cell Science, University of Manitoba, Manitoba R3E 0J9, Canada.
4
Hebei University of Science and Technology, Shijiazhuang 050018, Hebei Province, China.

Abstract

Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxidative stress is characterized by the overproduction of reactive oxygen species, which can induce mitochondrial DNA mutations, damage the mitochondrial respiratory chain, alter membrane permeability, and influence Ca(2+) homeostasis and mitochondrial defense systems. All these changes are implicated in the development of these neurodegenerative diseases, mediating or amplifying neuronal dysfunction and triggering neurodegeneration. This paper summarizes the contribution of oxidative stress and mitochondrial damage to the onset of neurodegenerative eases and discusses strategies to modify mitochondrial dysfunction that may be attractive therapeutic interventions for the treatment of various neurodegenerative diseases.

KEYWORDS:

Alzheimer's disease; Parkinson's disease; amyotrophic lateral sclerosis; grants-supported paper; mitochondrial damage; neural regeneration; neurodegenerative diseases; neuroregeneration; oxidative stress; reactive oxygen species; respiratory chain

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