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Diabetes. 2015 Jan;64(1):291-8. doi: 10.2337/db14-0563. Epub 2014 Sep 3.

Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.

Author information

1
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
2
Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore.
3
Department of Genetics, University of North Carolina, Chapel Hill, NC.
4
Department of Nutrition, Harvard School of Public Health, Boston, MA.
5
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
6
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
7
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Integrated Molecular Science on Metabolic Diseases, 22nd Century Medical and Research Center, The University of Tokyo, Tokyo, Japan.
8
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong.
9
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.
10
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA.
11
Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
12
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
13
Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
14
Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
15
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
16
State Key Laboratory of Cardiovascular Disease, Department of Epidemiology, National Center for Cardiovascular Diseases, Beijing, China Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences, Beijing, China Peking Union Medical College, Beijing, China.
17
Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines.
18
Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan.
19
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
20
Department of Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.
21
Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
22
Shanghai Municipal Center for Disease Control & Prevention, Shanghai, China.
23
Human Genetics Center, The University of Texas School of Public Health, Houston, TX.
24
Department of Nutrition, University of North Carolina, Chapel Hill, NC.
25
Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan.
26
Institute for Human Genetics, University of California, San Francisco, San Francisco, CA.
27
Center for Human Genetics, Duke University Medical Center, Durham, NC.
28
Centre for Molecular Epidemiology, National University of Singapore, Singapore, Singapore Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore.
29
Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
30
Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Toon, Japan.
31
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea.
32
Department of Occupational and Environmental Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
33
Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea.
34
Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
35
Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Toon, Japan.
36
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan Department of Medicine, National University of Singapore, Singapore, Singapore Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.
37
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea hanbokghee@gmail.com yooncho33@hallym.ac.kr kbj6181@hanmail.net.
38
Department of Biomedical Science, Hallym University, Chuncheon, Korea hanbokghee@gmail.com yooncho33@hallym.ac.kr kbj6181@hanmail.net.

Abstract

Fasting plasma glucose (FPG) has been recognized as an important indicator for the overall glycemic state preceding the onset of metabolic diseases. So far, most indentified genome-wide association loci for FPG were derived from populations with European ancestry, with a few exceptions. To extend a thorough catalog for FPG loci, we conducted meta-analyses of 13 genome-wide association studies in up to 24,740 nondiabetic subjects with East Asian ancestry. Follow-up replication analyses in up to an additional 21,345 participants identified three new FPG loci reaching genome-wide significance in or near PDK1-RAPGEF4, KANK1, and IGF1R. Our results could provide additional insight into the genetic variation implicated in fasting glucose regulation.

PMID:
25187374
PMCID:
PMC4274808
DOI:
10.2337/db14-0563
[Indexed for MEDLINE]
Free PMC Article

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