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Methods Mol Biol. 2012;818:109-17. doi: 10.1007/978-1-61779-418-6_8.

Protein profiling of cerebrospinal fluid.

Author information

1
Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Anja.hviid.simonsen@rh.regionh.dk

Abstract

The cerebrospinal fluid (CSF) perfuses the brain and spinal cord. CSF contains proteins and peptides important for brain physiology and potentially also relevant for brain pathology. Hence, CSF is the perfect source to search for new biomarkers to improve diagnosis of neurological diseases as well as to monitor the performance of disease-modifying drugs. This chapter presents methods for SELDI-TOF profiling of CSF as well as useful advice regarding pre-analytical factors to be considered.

PMID:
22083819
DOI:
10.1007/978-1-61779-418-6_8
[Indexed for MEDLINE]

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