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J Nat Prod. 2007 Jun;70(6):1039-42. Epub 2007 May 10.

Isoprenylated flavonoids from the stem bark of Erythrina abyssinica.

Author information

1
Korea Research Institute of Bioscience and Biotechnology, 52 Eoun-dong, Yuseong-gu, Daejeon 305-806, Korea.

Abstract

Three new prenylated flavanones, abyssinoflavanones V, VI, and VII (1-3), together with eight known flavanones (4-11) and two chalcones (12-13), were isolated from the stem bark of Erythrina abyssinica. Their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates, with the exception of 1 and 8, strongly inhibited PTP1B activity in an in vitro assay with IC50 values ranging from 14.2 +/- 1.7 to 26.7 +/- 1.2 microM.

PMID:
17489632
DOI:
10.1021/np060477+
[Indexed for MEDLINE]

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