Format

Send to

Choose Destination
Hypertension. 2018 May;71(5):848-857. doi: 10.1161/HYPERTENSIONAHA.117.10479. Epub 2018 Mar 12.

Blood Pressure Measurement in SPRINT (Systolic Blood Pressure Intervention Trial).

Author information

1
From the Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J., W.C.C.); Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (P.K.W.); Preventive Medicine Section, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Division of Cardiovascular Sciences (J.A.C., J.K.S.) and Clinical Applications and Prevention Branch (L.J.F.), National Heart, Lung, and Blood Institute; Division of Public Health Sciences, Department of Biostatistical Sciences (G.W.E., W.T.A., D.M.R.) and Section on Nephrology (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension and Medical Service (S.B.) and Division of Nephrology and Hypertension (A.K.C.), Veterans Affairs Salt Lake City Healthcare System, University of Utah; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Diseases (S.O.), University of Alabama at Birmingham; and Division of Nephrology and Hypertension, Louis Stokes Cleveland VA Medical Center (M.R.) and Division of Nephrology and Hypertension (J.T.W.), University Hospitals Cleveland Medical Center, Case Western Reserve University, OH. kjohnson@uthsc.edu.
2
From the Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis (K.C.J., W.C.C.); Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (P.K.W.); Preventive Medicine Section, Memphis Veterans Affairs Medical Center, TN (W.C.C.); Division of Cardiovascular Sciences (J.A.C., J.K.S.) and Clinical Applications and Prevention Branch (L.J.F.), National Heart, Lung, and Blood Institute; Division of Public Health Sciences, Department of Biostatistical Sciences (G.W.E., W.T.A., D.M.R.) and Section on Nephrology (M.V.R.), Wake Forest School of Medicine, Winston-Salem, NC; Division of Nephrology and Hypertension and Medical Service (S.B.) and Division of Nephrology and Hypertension (A.K.C.), Veterans Affairs Salt Lake City Healthcare System, University of Utah; Division of Preventive Medicine (C.E.L.) and Division of Cardiovascular Diseases (S.O.), University of Alabama at Birmingham; and Division of Nephrology and Hypertension, Louis Stokes Cleveland VA Medical Center (M.R.) and Division of Nephrology and Hypertension (J.T.W.), University Hospitals Cleveland Medical Center, Case Western Reserve University, OH.

Abstract

Recent publications have stated that the blood pressure (BP) measurement technique used in SPRINT (Systolic Blood Pressure Intervention Trial) was unattended. However, the SPRINT protocol does not address the issue of attendance. A survey was conducted immediately after SPRINT closeout visits were completed to inquire whether BP measurements were usually attended or unattended by staff. There were 4082 participants at 38 sites that measured BP after leaving the participant alone the entire time (always alone), 2247 at 25 sites that had personnel in the room the entire time (never alone), 1746 at 19 sites that left the participant alone only during the rest period (alone for rest), and 570 at 6 sites that left the participant alone only during the BP readings (alone for BP measurement). Similar systolic and diastolic BPs within randomized groups were noted during follow-up at the majority of visits in all 4 measurement categories. In the always alone and never alone categories, the intensive group had a similarly reduced risk for the primary outcome compared with the standard group (hazard ratio, 0.62; 95% confidence interval, 0.51-0.76 and hazard ratio, 0.64; 95% confidence interval, 0.46-0.91, respectively; pairwise interaction P value, 0.88); risk was not significantly reduced for the intensive group in the smaller alone-for-rest and the alone-for-BP-measurement categories. Similar BP levels and cardiovascular disease risk reduction were observed in the intensive group in SPRINT participants whether the measurement technique used was primarily attended or unattended.

CLINICAL TRIAL REGISTRATION:

URL: http://www.clinicaltrials.gov. Unique identifier: NCT01206062.

KEYWORDS:

blood pressure; cardiovascular diseases; hazard ratio; hypertension; risk

PMID:
29531173
PMCID:
PMC5967644
[Available on 2019-05-01]
DOI:
10.1161/HYPERTENSIONAHA.117.10479

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center