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BMC Complement Altern Med. 2017 Mar 11;17(1):152. doi: 10.1186/s12906-017-1663-x.

Calcium - Magnesium imbalance implicated in benign prostatic hyperplasia and restoration by a phytotherapeutic drug - Croton membranaceus Müll.Arg.

Author information

1
University of Ghana School of Biomedical and Allied Health Sciences (SBAHS), Korle Bu, Ghana. gasare@chs.edu.gh.
2
Chemical Pathology Unit, Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P.O. Box KB 143, Korle-bu, Accra, Ghana. gasare@chs.edu.gh.
3
Department of Molecular Medicine, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
4
Department of Pharmacy, Ghana Police Hospital, Cantonments, Accra, Ghana.
5
Noguchi Memorial Institute for Medical Research (NMIMR), University of Ghana, Legon, Ghana.
6
University of Ghana School of Biomedical and Allied Health Sciences (SBAHS), Korle Bu, Ghana.
7
Department of Urology, Ghana Police Hospital, Cantonments, Accra, Ghana.
8
Directorate of Research, Walter Sisulu University, Mthatha, South Africa.

Abstract

BACKGROUND:

Calcium (Ca)- magnesium (Mg) imbalance is implicated in prostate cancer. Ca/Mg ratio increases or decreases with proliferation or apoptosis, respectively. The study examined whether this Ca/Mg imbalance exists in BPH patients and the effect of a phytotherapeutic drug on the Ca/Mg ratio.

METHODS:

Thirty (30) BPH patients who used the ethanolic root extract of Croton membranaceus (60 mg/day) for 3 months were examined for serum Ca, Mg, phosphate, parathyroid hormone (PTH), vitamin D, prostate specific antigen (PSA) levels and renal function tests (RFT) before (BT) and after treatment (AT) alongside thirty (30) controls. Twenty (20) trace element including Mg and Ca were determined in the drug by neutron activation analysis (NAA).

RESULTS:

RFT, PTH and vitamin D for BT, AT and controls (C) were normal. Mean PSA was 1.0 ± 0.64 (C), 27.9 ± 19.0 (BT) and 16.2 ± 11.8 ng/mL (AT) (p = 0.002). Mg, Ca/Mg ratio BT, AT and control were significantly different (p = 0.0001, respectively). After treatment, Mg and Ca/Mg ratio were not different from controls. The prevalence of Ca/Mg imbalance was 80% (BT), 13.3% (AT) and 3.3% (control group).

CONCLUSION:

Ca/Mg ratio imbalance is associated with BPH. This has previously not been demonstrated. The imbalance was significantly corrected after treatment with the phytotherapeutic drug.

KEYWORDS:

Benign prostatic hyperplasia; Calcium; Croton membranaceus; Magnesium

PMID:
28284204
PMCID:
PMC5346265
DOI:
10.1186/s12906-017-1663-x
[Indexed for MEDLINE]
Free PMC Article

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