Protein Family Models

This domain is found in fatty acid kinase subunit A (FakA) from a bacterial fatty acid kinase (Fak) system and it is localised between Pfam:PF02734 and Pfam:PF13684. Two major human pathogens, Staphylococcus and Streptococcus, use this machinery to scavenge host fatty acids [1]. The Fak complex consists of an ATP-binding subunit FakA, which interacts with varied FakB (fatty acid-binding protein) isoforms, and synthesises acyl-phosphate from extracellular fatty acids [1]. FakA comprises three domains, denoted as FakA_N, FakA_M and FakA_C in [1] of which the middle domain is represented in this entry. It consists of four alpha-helices, four beta-strands and several long loops, containing a zinc finger motif. It shows similarities to the yeast copper chaperone ATX1, a metallochaperone/metal-binding protein. [1]. 36054360. Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging. Shi Y, Zang N, Lou N, Xu Y, Sun J, Huang M, Zhang H, Lu H, Zhou C, Feng Y;. Sci Adv. 2022;8:eabq3944. (from Pfam)

Date:

2024-10-16

This domain is found at the C-terminal of FakA (fatty acid subunit A) proteins, which is part of the fatty acid kinase machinery [1]. In the human pathogens Staphylococcus and Streptococcus, this system is used to scavenge host fatty acids. FakA is an ATP-binding subunit which interacts with varied FakB (fatty acid-binding protein) isoforms and synthesises acyl-phosphate from extracellular fatty acids [1]. FakA comprises three domains (FakA_N, FakA_M and FakA_C) and resembles an evolutionary mimic of the DhaK-DhaL kinase system. This entry represents FakA_C, which acts as a recipient of fatty acids transferred from FakB in the context of Fak activity [1]. [1]. 36054360. Structure and mechanism for streptococcal fatty acid kinase (Fak) system dedicated to host fatty acid scavenging. Shi Y, Zang N, Lou N, Xu Y, Sun J, Huang M, Zhang H, Lu H, Zhou C, Feng Y;. Sci Adv. 2022;8:eabq3944. (from Pfam)

Date:

2024-10-16

This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family. (from Pfam)

Date:

2024-08-14

DAK2 domain-containing protein similar to Staphylococcus aureus SAB1090

Date:

2018-10-15

This model describes a protein family that contains an N-terminal DAK2 domain (PF02734), so named because of similarity to the dihydroxyacetone kinase family family. The GTP-binding protein CgtA (a member of the obg family) is a bacterial GTPase associated with ribosome biogenesis, and it has a characteristic extension (TIGR03595) in certain lineages. This protein family described here was found, by the method of partial phylognetic profiling, to have a phylogenetic distribution strongly correlated to that of TIGR03595. This correlation implies some form of functional coupling.

Date:

2019-09-10