Protein Family Models

This family of presumed lipases and related enzymes are similar to Pfam:PF00657. [1]. 7610479. A new family of lipolytic enzymes?. Upton C, Buckley JT;. Trends Biochem Sci 1995;20:178-179.. [2]. 10801485. Rhamnogalacturonan acetylesterase elucidates the structure and. function of a new family of hydrolases.. Molgaard A, Kauppinen S, Larsen S;. Structure Fold Des 2000;8:373-383. (from Pfam)

Date:

2024-04-03

Methylaspartate ammonia-lyase EC:4.3.1.2 catalyses the second step of fermentation of glutamate. It is a homodimer. This family represents the N-terminal region of Methylaspartate ammonia-lyase. This domain is structurally related to Pfam:PF03952 [2]. This domain is associated with the catalytic domain Pfam:PF07476. [1]. 1420191. Cloning, sequencing, and expression in Escherichia coli of the. Clostridium tetanomorphum gene encoding beta-methylaspartase and. characterization of the recombinant protein.. Goda SK, Minton NP, Botting NP, Gani D;. Biochemistry 1992;31:10747-10756.. [2]. 11796115. Insights into enzyme evolution revealed by the structure of. methylaspartate ammonia lyase.. Levy CW, Buckley PA, Sedelnikova S, Kato Y, Asano Y, Rice DW,. Baker PJ;. Structure (Camb) 2002;10:105-113.. [3]. 11748244. The structure of 3-methylaspartase from Clostridium. tetanomorphum functions via the common enolase chemical step.. Asuncion M, Blankenfeldt W, Barlow JN, Gani D, Naismith JH;. J Biol Chem 2002;277:8306-8311. (from Pfam)

Date:

2024-04-03

The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerisation [2]. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain [3]. [1]. 9697411. The APECED polyglandular autoimmune syndrome protein, AIRE-1,. contains the SAND domain and is probably a transcription factor.. Gibson TJ, Ramu C, Gemund C, Aasland R;. Trends Biochem Sci 1998;23:242-244.. [2]. 11427895. The SAND domain structure defines a novel DNA-binding fold in. transcriptional regulation.. Bottomley MJ, Collard MW, Huggenvik JI, Liu Z, Gibson TJ,. Sattler M;. Nat Struct Biol 2001;8:626-633.. [3]. 17646893. The VARL gene family and the evolutionary origins of the master. cell-type regulatory gene, regA, in Volvox carteri.. Duncan L, Nishii I, Harryman A, Buckley S, Howard A, Friedman. NR, Miller SM;. J Mol Evol. 2007;65:1-11. (from Pfam)

Date:

2024-04-03