Protein Family Models

Anthrax toxin has three components, called edema factor (EF), lethal factor (LF), and protective antigen (PA).PA binds to receptors on target cells, undergoes cleavage that allows it to form ring-shaped oligomers, and then binds either EF to form edema toxin, or LF to form lethal toxin. After internalization, under the acidic conditions of the endosome, PA forms a channel that allows either EF or LF to enter the cytosol of target cells. Lethal factor is a zinc-dependent metalloproteinase that activates host cell mitogen-activated protein kinase kinases.

Gene:

lef

Date:

2018-01-16