Protein Family Models

This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family [1] after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonise different TGF beta Pfam:PF00019 ligands [1]. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo [2]. (from Pfam)

Date:

2023-12-12

The viral core protein forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane. The core protein has been shown, by yeast two-hybrid assay to interact with cellular DEAD box helicases [1]. The N terminus of the core protein is involved in transcriptional repression [2]. (from Pfam)

Date:

2023-12-12

NUDIX hydrolase catalyzes the hydrolysis of nucleoside diphosphates linked to other moieties (X); it requires a divalent cation, such as Mg2+ or Mn2+ for its activity; similar to nucleoside triphosphatase YtkD

Date:

2022-08-10

germin family protein is a cupin domain-containing protein similar to oxalate oxidase (also called germin) that catalyzes the manganese-dependent oxidative decarboxylation of oxalate to carbon dioxide and hydrogen peroxide

Date:

2020-02-24

protein containing domains UBA_FAF2, Thioredoxin_like, and Ubiquitin_like_fold

Date:

2019-03-21

protein containing domains UBA_FAF2, UAS_ETEA, and Ubiquitin_like_fold

Date:

2019-03-21

FAS-associated factor 2 (FAF2) plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins

Date:

2023-05-11

protein containing domains UBA_FAF2, Thioredoxin_like, and UBX_UBXN3B

Date:

2019-03-21

UBA (ubiquitin-associated) and UBX domain-containing protein binds ubiquitin and may participate in the regulation of protein degradation; also contains a UAS domain

Date:

2022-06-06

Thioredoxin_like and UBX_UBXN3B domain-containing protein

Date:

2019-03-21

protein containing domains HCV_capsid, HCV_core, and HCV_env

Date:

2019-03-21

protein containing domains HCV_capsid, HCV_core, and HCV_env

Date:

2017-03-02

protein containing domains HCV_capsid, HCV_core, HCV_env, and HCV_NS1

Date:

2017-03-02

protein containing domains SAND, ROM1, and SAM_Samd7,11

Date:

2017-03-02

hepatitis C virus capsid and core domain-containing protein, which forms the internal viral coat that encapsidates the genomic RNA and is enveloped in a host cell-derived lipid membrane

Date:

2020-12-14

SAND and SAM_superfamily domain-containing protein

Date:

2017-03-02

plant UBX domain-containing protein 10 (PUX10) is involved in a protein degradation pathway at lipid droplets, mediating an interaction between polyubiquitinated proteins targeted for degradation and downstream effectors such as CDC48

Date:

2022-06-06

UBA_FAF and UAS domain-containing protein

Date:

2019-03-21

protein containing domains PKc_like, MYSc_Myo3, and PTZ00121

Date:

2019-03-21

nudix_YtkD family protein

Date:

2017-03-02