Protein Family Models

The CLCA family of calcium-activated chloride channels has been identified in many epithelial and endothelial cell types as well as in smooth muscle cells [1] and has four or five putative transmembrane regions. Additionally to their role as chloride channels some CLCA proteins function as adhesion molecules and may also have roles as tumour suppressors [2]. This protein cleaves itself into an N-terminal portion and a C-terminal portion. The N-terminus contains an HEXXHXXXGXXDE motif which is essential for proteolytic cleavage [3-4]. [1][1]. 1189605611896056. Molecular and functional characterization of a murineMolecular and functional characterization of a murine calcium-activated chloride channel expressed in smooth muscle.calcium-activated chloride channel expressed in smooth muscle. Elble RC, Ji G, Nehrke K, DeBiasio J, Kingsley PD, Kotlikoff MI,Elble RC, Ji G, Nehrke K, DeBiasio J, Kingsley PD, Kotlikoff MI, Pauli BU;Pauli BU;. J Biol Chem 2002;277:18586-18591.J Biol Chem 2002;277:18586-18591. [2][2]. 1528422315284223. Molecular and functional analyses of two new calcium-activatedMolecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine.chloride channel family members from mouse eye and intestine. Evans SR, Thoreson WB, Beck CL;Evans SR, Thoreson WB, Beck CL;. J Biol Chem 2004;279:41792-41800.J Biol Chem 2004;279:41792-41800. [3][3]. 2235074522350745. Impaired autoproteolytic cleavage of mCLCA6, a murine integralImpaired autoproteolytic cleavage of mCLCA6, a murine integral membrane protein expressed in enterocytes, leads to cleavage atmembrane protein. TRUNCATED at 1650 bytes (from Pfam)

Date:

2025-02-20

This family consists of several mid-1-related chloride channels. mid-1-related chloride channel (MCLC) proteins function as a chloride channel when incorporated in the planar lipid bilayer [1]. [1][1]. 1127905711279057. Identification of a novel chloride channel expressed in theIdentification of a novel chloride channel expressed in the endoplasmic reticulum, golgi apparatus, and nucleus.endoplasmic reticulum, golgi apparatus, and nucleus. Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I;Nagasawa M, Kanzaki M, Iino Y, Morishita Y, Kojima I;. J Biol Chem 2001;276:20413-20418.J Biol Chem 2001;276:20413-20418. (from Pfam)

Date:

2025-02-20

This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 (Swiss:P35523) is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney [3]. These proteins contain two Pfam:PF00571 domains. [1][1]. 92523649252364. Reconstitution of functional voltage-gated chloride channelsReconstitution of functional voltage-gated chloride channels from complementary fragments of CLC-1.from complementary fragments of CLC-1. Schmidt-Rose T, Jentsch TJ;Schmidt-Rose T, Jentsch TJ;. J Biol Chem 1997;272:20515-20521.J Biol Chem 1997;272:20515-20521. [2][2]. 88577338857733. Mutations in the human skeletal muscle chloride channel geneMutations in the human skeletal muscle chloride channel gene (CLCN1) associated with dominant and recessive myotonia(CLCN1) associated with dominant and recessive myotonia congenita.congenita. Zhang J, George AL Jr, Griggs RC, Fouad GT, Roberts J,Zhang J, George AL Jr, Griggs RC, Fouad GT, Roberts J, Kwiecinski H, Connolly AM, Ptacek LJ;Kwiecinski H, Connolly AM, Ptacek LJ;. Neurology 1996;47:993-998.Neurology 1996;47:993-998. [3][3]. 1118289411182894. ClC chloride channels.ClC chloride channels. Mindell JA, Maduke M;Mindell JA, Maduke M;. Genome Biol 2001;2:REVIEWS3003.Genome Biol 2001;2:REVIEWS3003. (from Pfam)

Date:

2025-02-20

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2024-09-09

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2024-09-09

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2024-02-09

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2024-02-09

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2023-08-15

voltage-gated chloride channel family protein similar to Salmonella enterica ion-transport protein YfeO

Date:

2023-06-15

ClcB-like voltage-gated chloride channel protein is a ClC family voltage-gated chloride channel protein that catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2022-09-13

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2019-03-21

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2019-03-21

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator| ClcB-like voltage-gated chloride channel protein is a ClC family voltage-gated chloride channel protein that catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2019-03-21

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2019-02-11

CBS (cystathione beta synthase) domain-containing protein may bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet; similar to Arabidopsis thaliana CBS domain-containing protein CBSX6| ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2019-03-21

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2019-02-06

ClC family voltage-gated chloride channel protein catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2021-10-06

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2018-08-20

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2019-02-06

ClC family voltage-gated chloride channel protein containing a C-terminal CBS pair domain, catalyzes the selective flow of Cl(-) ions across the cellular membrane

Date:

2019-03-21