nuclear body protein SP140 isoform X26 [Homo sapiens]

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SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response. [J Immunother Cancer. 2022]
SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response.
Tanagala KKK, Morin-Baxter J, Carvajal R, Cheema M, Dubey S, Nakagawa H, Yoon A, Cheng YL, Taylor A, Nickerson J, et al. J Immunother Cancer. 2022 Dec; 10(12).
Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain. [Biochim Biophys Acta Gen Subj....]
Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain.
Zucchelli C, Tamburri S, Filosa G, Ghitti M, Quilici G, Bachi A, Musco G. Biochim Biophys Acta Gen Subj. 2019 Feb; 1863(2):456-465. Epub 2018 Nov 19.
SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition. [Hum Mol Genet. 2018]
SP140 regulates the expression of immune-related genes associated with multiple sclerosis and other autoimmune diseases by NF-κB inhibition.
Karaky M, Fedetz M, Potenciano V, Andrés-León E, Codina AE, Barrionuevo C, Alcina A, Matesanz F. Hum Mol Genet. 2018 Dec 1; 27(23):4012-4023.

RefSeq genomic sequence
See the genomic reference sequence for the SP140 gene (NG_051286.2).
RefSeq mRNA
See reference mRNA sequence for the SP140 gene (XM_017003249.2).
RefSeq protein isoforms
See 71 reference sequence protein isoforms for the SP140 gene.

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Protein