RecName: Full=Cyclin-dependent kinase 12; AltName: Full=Cdc2-related k - Protein

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Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release. [Nucleic Acids Res. 2023]
Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release.
Wang Z, Himanen SV, Haikala HM, Friedel CC, Vihervaara A, Barborič M. Nucleic Acids Res. 2023 Nov 10; 51(20):10970-10991.
Prognostic and clinicopathological value of CDK12 mutation in prostate cancer: a meta-analysis. [Expert Rev Anticancer Ther. 2023]
Prognostic and clinicopathological value of CDK12 mutation in prostate cancer: a meta-analysis.
Zhang W, Zhou L, Di J. Expert Rev Anticancer Ther. 2023 Feb; 23(2):207-216. Epub 2023 Feb 3.
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma. [Nat Commun. 2022]
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean É, Guérin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, et al. Nat Commun. 2022 Oct 29; 13(1):6457. Epub 2022 Oct 29.

RefSeq genomic sequence
See the genomic reference sequence for the CDK12 gene (NG_065324.1).
RefSeq protein isoforms
See 98 reference sequence protein isoforms for the CDK12 gene.

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Q9NYV4 [Domain Mapping of Disease Mut...]
Q9NYV4
Domain Mapping of Disease Mutations
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Protein