RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full - Protein

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IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis. [Int Immunopharmacol. 2023]
IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis.
An C, Sun F, Liu C, Huang S, Xu T, Zhang C, Ge S. Int Immunopharmacol. 2023 Oct; 123:110795. Epub 2023 Aug 17.
7-Ketocholesterol Promotes Retinal Pigment Epithelium Senescence and Fibrosis of Choroidal Neovascularization via IQGAP1 Phosphorylation-Dependent Signaling. [Int J Mol Sci. 2023]
7-Ketocholesterol Promotes Retinal Pigment Epithelium Senescence and Fibrosis of Choroidal Neovascularization via IQGAP1 Phosphorylation-Dependent Signaling.
Wang H, Ramshekar A, Cung T, Wallace-Carrete C, Zaugg C, Nguyen J, Stoddard GJ, Hartnett ME. Int J Mol Sci. 2023 Jun 17; 24(12). Epub 2023 Jun 17.
The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling. [J Cell Biol. 2023]
The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling.
Thines L, Roushar FJ, Hedman AC, Sacks DB. J Cell Biol. 2023 Jun 5; 222(6). Epub 2023 Apr 18.

RefSeq genomic sequence
See the genomic reference sequence for the IQGAP1 gene (NG_052946.1).
RefSeq protein isoforms
See 3 reference sequence protein isoforms for the IQGAP1 gene.

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P46940 [Domain Mapping of Disease Mut...]
P46940
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full=p195
RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full=p195
gi|1170586|sp|P46940.1|IQGA1_HUMAN

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