methylated DNA protein cysteine methyltransferase, partial [Homo sapie - Protein

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Protein 3D Structure

HUMAN O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE COVALENTLY CROSSLINKED TO DNA

PDB: 1T39

Source: Homo sapiens, synthetic construct

Method: X-ray Diffraction

Resolution: 3.3 Å

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Articles about the MGMT gene

Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression. [Front Immunol. 2024]
Glioblastoma with high O6-methyl-guanine DNA methyltransferase expression are more immunologically active than tumors with low MGMT expression.
Kushihara Y, Tanaka S, Kobayashi Y, Nagaoka K, Kikuchi M, Nejo T, Yamazawa E, Nambu S, Kugasawa K, Takami H, et al. Front Immunol. 2024; 15:1328375. Epub 2024 Jan 15.
Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma. [Int J Mol Sci. 2024]
Pyrosequencing Analysis of O-6-Methylguanine-DNA Methyltransferase Methylation at Different Cut-Offs of Positivity Associated with Treatment Response and Disease-Specific Survival in Isocitrate Dehydrogenase-Wildtype Grade 4 Glioblastoma.
Silva FFVE, Di Domenico M, Caponio VCA, Pérez-Sayáns M, Camolesi GCV, Rojo-Álvarez LI, Ballini A, García-García A, Padín-Iruegas ME, Suaréz-Peñaranda JM. Int J Mol Sci. 2024 Jan 3; 25(1). Epub 2024 Jan 3.
Total DNA methylation profile in assessing the MGMT gene promoter status in malignant gliomas. [Zh Vopr Neirokhir Im N N Burde...]
Total DNA methylation profile in assessing the MGMT gene promoter status in malignant gliomas.
Petrova EI, Galstyan SA, Telysheva EN, Ryzhova MV. Zh Vopr Neirokhir Im N N Burdenko. 2023; 87(6):52-58.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the MGMT gene (NG_052673.1).
RefSeq protein
See the reference protein sequence for methylated-DNA--protein-cysteine methyltransferase (NP_002403.3).

More about the MGMT gene

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repai...

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reagent reviews [ExactAntigen/Labome]
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ExactAntigen/Labome
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methylated DNA protein cysteine methyltransferase, partial [Homo sapiens]

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