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Babesia bovis genome view
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At present, none of the contigs from the current public WGS assembly have been placed on chromosomes so you cannot browse the sequence

  • querying Map Viewer for a known gene name, symbol, or locus-tag, e.g., merozoite surface antigen-1 or BBOV_I003060.
  • querying Map Viewer for accession numbers, e.g., XM_001608906 or NW_001820854.
  • searching Gene for B.bovis genes that have been annotated on the genome.
  • searching by sequence using BLAST against the genome. Results from a BLAST sequence alignment can be displayed in Map Viewer by clicking on the Genome View button or on the accession numbers of the results.

     Lineage: Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida; Babesiidae; Babesia; Babesia bovis

Babesia bovis is a haemoprotozoan parasite that causes disease in cattle. Babesiosis is one of the world's most severe tick-borne problems of cattle in temperate and tropical regions, responsible for great economic loss in lifestock in developing countries. Along with organisms such as Toxoplasma gondii, Eimeria tenella and Plasmodium falciparum, B. bovis have plastid-like DNA.The pathology caused by acute Babesia bovis infection is similar to that seen in severe human malaria caused by P. falciparum infection, what makes this disease an important model to study malaria, in particular, the pathological aspects of cerebral malaria.

The B. bovis genome is approximately 9.4 Mb, organized in four chromosomes, with sizes of 1.4, 2.0, 2.8 and 3.2 Mb.

A combined sequencing approach consisting of a clone by clone and whole genome shotgun method (8x coverage) was used to generate the complete genome sequence of B. bovis T2Bo strain. The gap closure phase of this sequencing project is near completion and has resulted in 13 contigs. Gene modeling and annotation of the genomic sequence data are in progress.

In addition to the genome project, the Sanger Center and the Department of Infectious Diseases and Immunology of Utrecht University are carrying on a research program to sequence thousands of cDNA clones from B. bovis. This initiative targets the identification of genes that are expressed during parasite infection. The EST sequences are intended for the identification of potential new vaccine and drug targets. In addition, this project will provide information about gene structure, which in turn can be used to train gene prediction software programs.

The EST project is funded by the Netherlands Foundation for the advancement of Tropical Research and the Dutch National Organisation for Scientific Research.

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Last modified: Feb 6 2008

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