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Giardia lamblia genome view
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At present, none of the contigs from the current public WGS assembly have been placed on chromosomes so you cannot browse the sequence data by chromosome. You can find sequenced regions of interest by:

  • querying Map Viewer for a known gene name, symbol, or locus-tag, e.g., Histone H3 or GL50803_14212.
  • querying Map Viewer for accession numbers, e.g., XM_001709453 or NW_001844178.
  • searching Gene for G. lamblia genes that have been annotated on the genome.
  • searching by sequence using BLAST against the genome. Results from a BLAST sequence alignment can be displayed in Map Viewer by clicking on the Genome View button or on the accession numbers of the results.

     Lineage: Eukaryota; Diplomonadida; Hexamitidae; Giardiinae; Giardia; Giardia intestinalis

The unicellular flagellate Giardia lamblia is a common cause of water- and food-borne diarrhea in humans and other mammals throughout the world. The prevalence of giardiasis in many countries in Tropical regions is very high, and mortalitity rates amongst neonates and undernourished children are not insignificant.

G. lamblia maintains a polyploid genome with two apparently identical nuclei. Additional differences this organism presents when compared to other protozoa and eukaryotes in general, is the lack of organelles such as nucleoli, peroxisomes, and mitochondria. The sequencing of the G. lamblia genome should provide insights into the selective advantage conferred by its two nuclei as well as facilitate the understanding of this organism's biology and pathogenicity.

The G.lamblia is 12 Mb, organized in 5 distinct chromosomes (chromosome polymorphism has been identified in different strains). Karyotyping analyses found chromosome sizes to range from 1.6 to over 3 Mb.

The genome sequencing of G. lamblia (WB strain, clone C6) is well under way at the Marine Biology Laboratories and involves collaborations with University of Texas at El Paso, University of Arizona at Tucson, and University of Illinois at Urbana-Champaign. The newest assembly and annotation is available in GenBank under project accession AACB02000000.

Funding for this project was provided by NIAID.

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Last modified: Feb 7 2008

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