The Genome Reference Consortium
Putting sequences into a chromosome context.
The original model for representing the genome assemblies was to use a single, preferred tiling path to produce a single consensus representation of the genome. Subsequent analysis has shown that for most mammalian genomes a single tiling path is insufficient to represent a genome in regions with complex allelic diversity. The GRC is now working to create assemblies that better represent this diversity and provide more robust substrates for genome analysis.
Transitioning to GRCh38 or GRCz10? Try the NCBI Remapping Service, which uses the same assembly-assembly alignments used by the GRC.
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