Reduction of Lethal Prostate Cancer Disparities in Underserved Hispanic/Latino Populations

This pilot study investigated the genomic underpinnings of prostate cancer in Puerto Rican Hispanic/Latino men, a group disproportionately affected by this disease, in terms of incidence, mortality and aggressiveness. By examining tumors from 35 patients for specific genetic mutations and gene expression patterns using cutting-edge genomic sequencing, we aimed to identify distinct genetic profiles that could influence the course of the disease and its treatment. Our initial findings suggest the presence of unique genomic characteristics in this population, offering a promising avenue for developing personalized treatments that could reduce the health disparities observed in these men. This study underscores the importance of including diverse ethnic groups in genomic studies to ensure that the published data required for personalized cancer care are available.

• Study Design:
  • Case Set
• Study Type:
  • Case Set
• Total number of consented subjects: 35
• Subject Sample Telemetry Report (SSTR)

Inclusion: Hispanic/Latino men who lived in Puerto Rico and were diagnosed with primary prostate adenocarcinoma.

• Primary Phenotype: Prostatic Neoplasms

• ERG
• TP53

• Principal Investigator
  • Jaime Matta, PhD. Ponce Health Sciences University, Ponce, Puerto Rico.
• Funding Sources
  • U54CA163071. National Institutes of Health, Bethesda, MD, USA.
  • U54CA163068. National Institutes of Health, Bethesda, MD, USA.
  • #W81XWH-21-1-0241. Department of Defense/US Army Award.
  • P30CA076292. National Institutes of Health, Bethesda, MD, USA.