| Jump to: | Authorized Access | | | Attribution | | | Authorized Requests |
- Study Description
-
Important Links and Information
-
Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
This study examines the molecular consequences of chromosome 17q gain in human neuroblastoma in the presence of MYCN amplification. Tumor samples derived from orthotopically implanted human embryonic stem cell line WA07 (H7; approval# NIHhESC-10-0061) containing MYCN overexpression, with or without the presence of chromosome 17q gain, were analyzed using bulk RNA sequencing to identify transcriptome regulation patterns associated with 17q gain. This data is made available through dbGaP. The study finds that 17q gain is linked to distinct transcriptional signatures and pathways implicated in tumor progression, and that specific genes located on chromosome 17q can accelerate tumorigenesis in vivo, including genes BIRC5, BRIP1, CBX2, CDC6, IGF2BP1, and TK1.
- Study Design:
- Case Set
- Study Type:
- Case Set
- RNA Sequencing
- Transcriptome Analysis
- Total number of consented subjects: 1
- Subject Sample Telemetry Report (SSTR)
-
Request access via Authorized Access
- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
-
- Primary Phenotype: Neuroblastoma
- Chromosome Aberrations
- Chromosomes, Human, Pair 17
- Links to Related Genes
- Authorized Data Access Requests
- Study Attribution
-
-
Principal Investigator
- Miller Huang. Children's Hospital Los Angeles, Los Angeles, CA, USA.
-
Graduate Student
- Wanqi Fang. Children's Hospital Los Angeles, Los Angeles, CA, USA.
-
Principal Investigator