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Study Description

Children with substantial African ancestry are observed to have less than half the incidence of B-cell acute lymphoblastic leukemia (B-ALL) than children of other continental ancestries. The Admixture Analysis of Acute Lymphoblastic Leukemia in African American Children study (ADMIRAL) was designed to investigate genes and loci that explain the unique risk profile of African American children. Germline DNA samples were obtained from Children's Oncology Group frontline protocols, the Michigan BioTrust for Health, and various academic hospital ALL banks. Cases represented a diagnosis of B-ALL between the ages of 0-20 years, and controls were matched on birth year, sex, and maternal race/ethnicity. All participants have reported Black/African American race or substantial inferred African genetic ancestry. Altogether, 840 cases and 392 internal controls are included in this submission. All samples were genotyped on the Illumina Global Diversity Array 8v1. Phenotype information includes case/control status and reported sex.

Authorized Access
Publicly Available Data
Study Inclusion/Exclusion Criteria

Inclusion Criteria:

Cases:

  • Diagnosis of B-ALL between the ages of 0-20 years
  • Reported Black/African American race or substantial inferred African genetic ancestry

Controls:

  • Age 0-20
  • Reported Black/African American race or substantial inferred African genetic ancestry

Exclusion Criteria:

Controls:

  • Cancer history
Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Links to Related Genes
Authorized Data Access Requests
Study Attribution
  • Principal Investigators
    • Logan G. Spector, PhD. University of Minnesota, Minneapolis, MN, USA.
    • Michael E. Scheurer, PhD. Baylor College of Medicine, Houston, TX, USA.
  • Co-Investigator
    • Cindy Im, PhD. University of Minnesota, Minneapolis, MN, USA.
  • Genomic Analyst
    • Andrew R. Raduski, PhD. University of Minnesota, Minneapolis, MN, USA.
  • Sequencing Center
    • University of Minnesota Genomics Center (UMGC). University of Minnesota, Minneapolis, MN, USA.
  • Funding Source
    • R01CA239701. National Institutes of Health, Bethesda, MD, USA.