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- Study Description
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Important Links and Information
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Request access via Authorized Access
- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
The Chicago Infant Mortality Study (CIMS) was a population-based, prospective, case-control study conducted in metropolitan Chicago, Cook County, Illinois, to examine the risk factors for sudden infant death syndrome (SIDS) among a primarily Black population. Eligible case infants were aged birth to one year where the cause of death was determined to be SIDS while eligible control infants were aged one month to one year who died of other sudden unexpected infant death (SUID) causes. Recruitment occurred between November 1993 and April 1996.
The goal of this ancillary multiomics study was to evaluate possible genetic and epigenetic determinates of SIDS and together with metabolomic profiles, identify novel clinical diagnostic tools to enable molecular autopsies and biomarkers to proactively identify and intervene in infants at greater risk of death from SIDS. The multiomics data was generated from medical examiner autopsy specimens and includes: whole exome sequencing genotypes; RNA-seq transcriptome and methylome profiles from autopsy heart tissue; and serum metabolomics profiles. The sample size available varies with the modality of the omics assay, but the total number of unique infants included is about 400.
- Study Design:
- Case-Control
- Study Type:
- Case-Control
- dbGaP estimated ancestry using GRAF-pop
- Total number of consented subjects: 407
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Study Inclusion/Exclusion Criteria
Inclusion:
Participation in CIMS from 1993 – 1997
Exclusion:
None
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Infant Death, Sudden
- Infant Mortality
- Authorized Data Access Requests
- Study Attribution
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Principal Investigator
- Fern R. Hauck. University of Virginia School of Medicine, Charlottesville, VA, USA.
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Co-Principal Investigators
- Josyf C. Mychaleckyj. University of Virginia School of Medicine, Charlottesville, VA, USA.
- Keith L. Keene. Thomas Harriot College of Arts and Sciences, East Carolina University, NC, USA.
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Funding Sources
- R01HD101518. National Institute of Child Health and Human Development, Bethesda, MD, USA.
- NO1-HD-3-3188. National Institute on Deafness and Other communication Disorders, Bethesda, MD, USA.
- U50/CCU300860-06. Centers for Disease Control and Prevention And the Association of Teachers of Preventive Medicine, Bethesda, MD, USA.
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Principal Investigator