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- Study Description
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Important Links and Information
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- Instructions for requestors
- Data Use Certification (DUC) Agreement
- Talking Glossary of Genetic Terms
Desmoplastic Small Round Cell Tumor (DSRCT) is an aggressive mesenchymal tumor driven by fusions between the disordered domain of the Ewing sarcoma RNA binding protein 1 (EWSR1) and the developmental transcription factor Wilms tumor 1 (WT1). We used genome-wide chromatin profiling to identify EWSR1-WT1-dependent gene regulatory networks and target genes. Our studies show that EWS-WT1 is a powerful activator of distal regulatory elements and controls an oncogenic gene expression program that characterizes primary DSRCTs. ChIP-seq profiles for histone marks in primary DSRCT samples are available through dbGaP.
- Study Design:
- Case Set
- Study Type:
- Case Set
- Total number of consented subjects: 2
- Subject Sample Telemetry Report (SSTR)
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- Authorized Access
- Publicly Available Data
- Link to other NCBI resources related to this study
- Selected Publications
- Diseases/Traits Related to Study (MeSH terms)
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- Primary Phenotype: Sarcoma
- Neoplasms
- Epigenomics
- Authorized Data Access Requests
- Study Attribution
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Principal Investigator
- Miguel Rivera. Massachusetts General Hospital, Boston, MA, USA.
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Co-Investigators
- Nicolo Riggi. University of Lausanne, Lausanne, Switzerland.
- Gaylor Boulay. Massachusetts General Hospital, Boston, MA, USA.
- Rui Dong. Massachusetts General Hospital, Boston, MA, USA.
- Liliane Broye. University of Lausanne, Lausanne, Switzerland.
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Principal Investigator