Impact of Genomic Variation on Function (IGVF) Consortium

The IGVF (Impact of Genomic Variation on Function) Consortium aims to understand how genomic variation affects genome function, which in turn impacts phenotype. The NHGRI is funding this collaborative program that brings together teams of investigators who will use state-of-the-art experimental and computational approaches to model, predict, characterize and map genome function, how genome function shapes phenotype, and how these processes are affected by genomic variation. These joint efforts will produce a catalog of the impact of genomic variants on genome function and phenotypes.

• Study Weblinks:
  • IGVF Website
  • IGVF Data Portal
• Study Design:
  • Collection
• Study Type:
  • Collection

• Primary Phenotype: Genomic Structural Variation

• Funding Sources
  • HG012047. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012022. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012009. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012103. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012053. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012012. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012076. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG011972. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG011986. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG011996. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012069. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG011966. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012070. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012079. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012039. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG011967. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012003. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012051. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012010. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG011989. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG011952. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012077. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG011969. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012059. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012064. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
  • HG012041. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
• Principal Investigators
  • Hao Wu. University of Pennsylvania, Philadelphia, PA, USA.
  • Hongjun Song. University of Pennsylvania, Philadelphia, PA, USA.
  • Predrag Radivojac. Northeastern University, Boston, MA, USA.
  • Soumya Raychaudhuri. Brigham and Women's Hospital, Boston, MA, USA.
  • Alkes Price. Harvard University, Cambridge, MA, USA.
  • Shamil Sunyaev. Brigham and Women's Hospital, Boston, MA, USA.
  • Christina Leslie. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Alexander Rudensky. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Charles Gersbach. Duke University, Durham, NC, USA.
  • Gregory Crawford. Duke University, Durham, NC, USA.
  • Tim Reddy. Duke University, Durham, NC, USA.
  • J. Michael Cherry. Stanford University, Palo Alto, CA, USA.
  • Ansuman Satpathy. Stanford University, Palo Alto, CA, USA.
  • Jesse Engreitz. Stanford University, Palo Alto, CA, USA.
  • Thomas Quertermous. Stanford University, Palo Alto, CA, USA.
  • Bradley Bernstein. Broad Institute, Cambridge, MA , USA.
  • Jason Buenrostro. Broad Institute, Cambridge, MA , USA.
  • William Lee Kraus. UT Southwestern, Dallas, TX, USA.
  • Gary Hon. UT Southwestern, Dallas, TX, USA.
  • Nikhil Munshi. UT Southwestern, Dallas, TX, USA.
  • Anshul Kundaje. Stanford University, Palo Alto, CA, USA.
  • Nadav Ahituv. University of California, San Francisco, CA, USA.
  • Martin Kircher. Berlin Institute of Health, Berlin, Germany.
  • Jay Shendure. University of Washington, Seattle, WA, USA.
  • Ting Wang. Washington University, St. Louis, MO, USA.
  • Feng Yue. Washington University, St. Louis, MO, USA.
  • Chongyuan Luo. University of California, Los Angeles, CA, USA.
  • Noah Zaitlen. University of California, San Francisco, CA, USA.
  • Kathrin Plath. University of California, Los Angeles, CA, USA.
  • Mark Craven. University of Wisconsin, Madison, WI, USA.
  • Andrew Allen. Duke University, Durham, NC, USA.
  • David Page. Duke University, Durham, NC, USA.
  • Bill Majoros. Duke University, Durham, NC, USA.
  • Hyejung Won. University of North Carolina, Chapel Hill, NC, USA.
  • Michael Love. University of North Carolina, Chapel Hill, NC, USA.
  • Karen Mohlke. University of North Carolina, Chapel Hill, NC, USA.
  • Danwei Huangfu. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Anna-Katerina Hadjantonakis. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Michael Beer. Johns Hopkins University, Baltimore, MD, USA.
  • Luca Pinello. Massachusetts General Hospital, Boston, MA, USA.
  • Guillaume Lettre. Montreal Heart Institute, Montreal, Quebec, Canada.
  • Daniel Bauer. Harvard Stem Cell Institute, Cambridge, MA, USA.
  • Richard Sherwood. Brigham and Women's Hospital, Boston, MA, USA.
  • Marc Vidal. Dana-Farber Cancer Institute, Boston, MA, USA.
  • Alan Boyle. University of Michigan, Ann Arbor, Michigan, USA.
  • Ali Mortazavi. University of California, Irvine, CA, USA.
  • Barbara Wold. Caltech, Pasadena, CA, USA.
  • Lea Starita. University of Washington, Seattle, WA, USA.
  • Doug Fowler. University of Washington, Seattle, WA, USA.
  • Maike Sander. University of California, San Diego, CA, USA.
  • Hannah Carter. University of California, San Diego, CA, USA.
  • Bing Ren. University of California, San Diego, CA, USA.
  • Kyle Gaulton. University of California, San Diego, CA, USA.
  • Manuel Garber. University of Massachusetts, Worcester, MA, USA.
  • Xihong Lin. Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Zhiping Weng. University of Massachusetts, Worcester, MA, USA.
  • Harinder Singh. University of Pittsburgh, Pittsburgh, PA, USA.
  • Nidhi Sahni. MD Anderson Cancer Center, Houston, TX, USA.
  • Jishnu Das. University of Pittsburgh, Pittsburgh, PA, USA.