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Study Description

The goal of this study is to deliver a detailed characterization of the patterns of disease dissemination at diagnosis, during progression and in response to therapy in high-risk neuroblastoma. Longitudinal and spatially distinct tumors were collected from patients. Clinical data includes diagnosis and treatment information. Biospecimen data includes whole genome sequencing (WGS) and whole transcriptome sequencing (WTS).

  • Study Design:
    • Tumor vs. Matched-Normal
  • Study Type:
    • Longitudinal Cohort
    • Transcriptome Sequencing
    • Whole Genome Sequencing
  • Total number of consented subjects: 129
  • Subject Sample Telemetry Report (SSTR)
Authorized Access
Publicly Available Data
  Link to other NCBI resources related to this study
Study Inclusion/Exclusion Criteria

All neuroblastoma patients treated at MSKCC with two or more tumors from distinct sites or time points were eligible for this study. No exclusion criteria.

Study History

Samples available through 1987 through 2021 were analyzed.

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Links to Related Genes
Authorized Data Access Requests
Study Attribution
  • Analyst
    • Gunes Gundem, PhD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Engineers
    • Max F. Levine. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Juan S. Medina-Martinez. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Juan E. Arango-Ossa. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Joe Zhou. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Clinicians
    • Stephen S. Roberts, MD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Barbara Spitzer, MD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Michael P. LaQuaglia, MD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Brian H. Kushner, MD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Sample Procurement
    • Irene Y. Cheung. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Yi Feng. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Nancy Bouvier. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Analysis Support
    • Loci Chadoutaud. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Matthieu Rita. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Georgios Asimomitis. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Cell Line Experiments
    • Daoqi You. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    • Filemon Dela Cruz, MD, PhD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Director of MSK Molecular Oncology
    • David B. Solit, MD, PhD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Research Donation Program Leadership
    • Christine A. Iacobuzio-Donahue, MD, PhD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Chair of MSK Department of Pediatrics
    • Andrew L. Kung, MD, PhD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Co-Investigator
    • Nai-Kong V. Cheung, MD, PhD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Principle Investigator
    • Elli Papaemmanuil, PhD. Memorial Sloan Kettering Cancer Center, New York, NY, USA.