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Study Description

Adverse effects of the coronavirus disease 2019 (COVID19) pandemic on US society, health, and economy are widespread. The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) aims to advance our knowledge on the impact of the COVID-19 pandemic in the United States. C4R is a diverse national prospective study comprising 14 long-standing prospective cohort studies and over 49,000 participants with extensive pre-COVID-19 phenotype data. C4R links pre-pandemic data on clinical and subclinical diseases and their risk factors, including behavior, cognition, biomarkers, and social determinants of health, to information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute and post-acute COVID-related illness. Ascertainment of COVID-19 infection occurs via standardized questionnaires, adjudication of COVID-related hospitalizations and deaths, and SARS-CoV-2 serosurvey via dried blood spot cards. C4R is investigating the following research questions: 1) how pre-existing health conditions affect risk of severe or prolonged COVID-19 related illness; 2) how SARS-CoV-2 infection and COVID-19 illness affect long-term health; and 3) how the pandemic has affected health-related behaviors and non-COVID health outcomes. This resource will allow evaluation of risk and resilience factors for COVID-19 severity and long-term health effects.

Cohort Description
The Northern Manhattan Study (NOMAS) is a study of the population of Washington Heights in Northern Manhattan. The ongoing study, which began in 1990, has enrolled over 4,400 people, some of whom have suffered a stroke or related neurological syndromes. As the cohort aged, the specific aims grew to include not only vascular determinants of stroke but also cognitive decline, mild cognitive impairment (MCI) and dementia. The overall goal of NOMAS is to investigate stroke risk factors in different race-ethnic groups. NOMAS is also committed to developing better stroke prevention programs to improve the health of the community. The Hispanic population in Northern Manhattan is largely Dominican, along with Puerto Rican, Cuban, and Central and South American components.

Data Being Submitted

  • Wave 1 questionnaire data includes 397 variables for up to 887 NOMAS participants in C4R
  • Wave 2 questionnaire data includes 448 variables for up to 815 NOMAS participants in C4R
  • Derived data includes 43 variables for up to 995 NOMAS participants in C4R
  • Phenotype data includes 113 variables for up to 995 NOMAS participants in C4R

Authorized Access
Publicly Available Data
  Link to other NCBI resources related to this study
Study Inclusion/Exclusion Criteria

All participants enrolled in the Northern Manhattan Study and alive as of March 1, 2020 were attempted for contact about participation in the C4R study. Patients were verbally consented. Those NOMAS participants who could not be reached or who refused participation were excluded from the C4R study.

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Authorized Data Access Requests
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Study Attribution
  • Principal Investigator
    • Elizabeth C. Oelsner, MD, MPH. Columbia University Irving Medical Center, New York, NY, USA.
  • Co-Principal Investigator
    • R. Graham Barr, MD, DrPH. Columbia University Irving Medical Center, New York, NY, USA.
  • Co-Investigator
    • Pallavi Balte, MBBS, MPH, PhD. Columbia University Irving Medical Center, New York, NY, USA.
  • Cohort Principal Investigator [KA1]
    • Mitchell Elkind, MD, MS, MPhil. Columbia University Irving Medical Center, New York, NY, USA.
  • Data Manager
    • Kevin Strobino. Columbia University Irving Medical Center, New York, NY, USA.