Infant Immune Responses to Early Life Vaccinations

Infants are vulnerable to life-threatening infections due to an immature immune system. For this reason, vaccinations are provided early in life to increase protection against infectious agents. However, there is a limited understanding on how routine vaccinations alter the different immune cell populations in infants. Here, we profiled peripheral blood mononuclear cells (PBMCs) from six 2-month-old infants at the time of their routine vaccinations. Infants received the standard vaccinations including DTaP (diphtheria, tetanus and acellular pertussis), IPV (inactivated polio vaccine), Hep B (hepatitis B), Hib (Haemophilus influenzae type B), Rotavirus, and PCV13 (pneumococcus conjugate vaccine). Samples were obtained before vaccination, and subsequently around one week, and two-month post-vaccination (n=18 samples). This study sheds light on the dynamic nature of the infant peripheral immune cell transcriptome upon initial routine vaccine exposure.

The processed data is available on GEO under GSE204716.

• Study Design:
  • Collection
• Study Type:
  • Clinical Cohort
  • Observational
• Total number of consented subjects: 6
• Subject Sample Telemetry Report (SSTR)

• BioProject
• Sequence Read Archive
• BioSample
• MeSH

• Primary Phenotype: Immunity
• Vaccinations
• Infant

• Principal Investigator
  • Octavio Ramilo, MD. Nationwide Children’s Hospital, Columbus, Ohio, USA.
• Funding Source
  • U01 AI131386. National Institute of Allergy and Infectious Diseases (NIAID), NIH, Rockville, MD, USA.
• Co-Investigators
  • Duygu Ucar, PhD. The Jackson Laboratory, Farmington, CT, USA.
  • Jacques Banchereau, PhD. The Jackson Laboratory, Farmington, CT, USA.