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Study Description

Adverse effects of the coronavirus disease 2019 (COVID19) pandemic on US society, health, and economy are widespread. The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) aims to advance our knowledge on the impact of the COVID-19 pandemic in the United States. C4R is a diverse national prospective study comprising 14 long-standing prospective cohort studies and over 49,000 participants with extensive pre-COVID-19 phenotype data. C4R links pre-pandemic data on clinical and subclinical diseases and their risk factors, including behavior, cognition, biomarkers, and social determinants of health, to information on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and acute and post-acute COVID-related illness. Ascertainment of COVID-19 infection occurs via standardized questionnaires, adjudication of COVID-related hospitalizations and deaths, and SARS-CoV-2 serosurvey via dried blood spot cards. C4R is investigating the following research questions: 1) how pre-existing health conditions affect risk of severe or prolonged COVID-19 related illness; 2) how SARS-CoV-2 infection and COVID-19 illness affect long-term health; and 3) how the pandemic has affected health-related behaviors and non-COVID health outcomes. This resource will allow evaluation of risk and resilience factors for COVID-19 severity and long-term health effects.

Cohort Description
Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is an ongoing population-based prospective cohort study of 16,415 community dwelling Hispanic/Latino adults aged 18-74 years at baseline, recruited from four urban field centers with large populations of Hispanics/ Latinos (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA). The primary goals of the HCHS/SOL are to describe: (1) the prevalence and incidence of cardiovascular, pulmonary, and other major chronic conditions (2) the risk and/or protective factors associated with these conditions; and (3) the relationships between the initial sociodemographic and health profiles and future health events in the target population.

Data Being Submitted
Wave 1 questionnaire data includes 397 variables for up to 9817 HCHS/SOL participants in C4R.
Wave 2 questionnaire data includes 448 variables for up to 7536 HCHS/SOL participants in C4R.
Derived data includes 43 variables for up to 11182 HCHS/SOL participants in C4R.
Phenotype data includes 113 variables for up to 11182 HCHS/SOL participants in C4R.

Authorized Access
Publicly Available Data
  Link to other NCBI resources related to this study
Study Inclusion/Exclusion Criteria

Please see phs000810.

Study History

Please see phs000810.

Selected Publications
Diseases/Traits Related to Study (MeSH terms)
Authorized Data Access Requests
See articles in PMC citing this study accession
Study Attribution
  • Principal Investigator
    • Elizabeth C. Oelsner, MD, MPH. Columbia University Irving Medical Center, New York, NY, USA.
  • Co-Principal Investigator
    • R. Graham Barr, MD, DrPH. Columbia University Irving Medical Center, New York, NY, USA.
  • Co-Investigator
    • Pallavi Balte, MBBS, MPH, PhD. Columbia University Irving Medical Center, New York, NY, USA.
  • Cohort Principal Investigator
    • Carmen Isasi, MD, PhD. Albert Einstein College of Medicine, Bronx, NY, USA.
    • Robert Kaplan, PhD. Albert Einstein College of Medicine, Bronx, NY, USA.
  • Cohort Co-Investigator
    • Jianwen Cai, PhD. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    • Daniela Sotres-Alvarez, DrPH. University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.